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SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS



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SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS 
STRUCTURE
 
Amanzholkyzy A. 
Scientific supervisor: Abilov Zh. A. 
Al-Farabi Kazakh National University 
arai13_95@list.ru 
 
In the case of the problem of antibiotic resistance in pathogenic microorganisms, 
the World Health Organization (WHO) urges the government of WHO member 
countries and scientists all over the world to intensify the search for new effective drugs 
that can withstand the spread of drug resistant microorganisms and the diseases caused 
by them. 
In a number of promising compounds for the control of drug-resistant pathogens, 
the semiorganic iodine coordination compounds with biologically active organic ligands 
and alkali metal halides are among the most perspective. Halogens have played an 
important role in the development of pharmaceuticals for several decades. The 
effectiveness of many complex molecules is significantly enhanced by the presence 
of halogen atoms. The majority of halogenated drugs contain fluorine, followed by 
chlorine, while those with bromine are rare. Only a few iodine-containing drugs are 
known, such as the thyroid hormone thyroxine, an anti-herpesvirus, the antiviral drug 
idoxuridine, and amiodaron, a class III antiarrhythmic agent. 
For a purposeful search for new iodine coordination compounds with biologically 
active ligands, it is necessary to study the influence of the ligand nature and structure of 
coordination compounds on pathogenic microorganisms at the molecular level, and to 
associate the structure with antimicrobial effectiveness.
It is necessary to find out the mechanism of action of biologically active 
compounds on pathogenic microorganisms at the molecular level. This formulation of 
the problem emphasizes the importance of knowledge of atomic structures of 
compounds. Of all the modern physicochemical methods for studying the atomic 
structure of molecules, X-ray diffraction analysis (XRD) is the most reliable technique.
The purpose of these studies was to determine and refine the crystal structure of 
the new coordination compound formed in the tryptophan:NaI:iodine system,and unit 
cell parameters were determined.A chemical structure of the compound wasdetermined 
by X-ray diffraction analysis asC
11
H
12
N
2
O
2
•(C
11
H
13
N
2
O
2
)
+
•Na

•2Н
2
О • (I
4
)
2-
. The 
coordination compound showed low toxicity and exhibited bactericidal activity against 
both susceptible and multiresistant strains of bacteria 
S. aureus

P. aeruginosa
, and 
E. 
coli
.
As a result semiorganic complex of iodine was synthesized and the crystal 
structure was observed 
C
11
H
12
N
2
O
2
•(C
11
H
13
N
2
O
2
)
+
•Na

•2Н
2
О •(I
4
)
2-

It has low cytotoxicity, 
direct antiviral effect, broad-spectrum antimicrobial activity against antibiotic-resistant 
strains of microorganisms and is therefore promising for further useas an active 
antimicrobial substance. 


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