Внутривузовская студенческая

58 
УДК: 615.272
 
 
THE ACTION OF ANTIOXIDANT SYSTEM IN THE CONDITION
 
 
OF TISSUES HYPOXIA
 
 
Orazbekov B., Muratova A., M., Duysenova K., Zhumagalieva J., Bіlisbek A.,
 
Amangeldiev N.
 
Scientific supervisor: Olzhayeva R.R., k.b.s., professor of Russian Academy of 
Natural Sciences
 
 
Semey Medical University,
 
NCJSC
 
, Semey city, Kazakhstan
 
Аctuality:
The disease from the point of biochemistry was greatly observed. Our 
organisms routinely are under the exposure of different pathogenic factors. The most 
frequent cause of cancerogenic, hyperaging changes in tissues is related to oxygen 
molecules and to its derivatives
 
Purpose: 
Тo survey the possible ways of the antioxidant system activation.
 
Materials and methods: 
Literature review is used. 
 
Results:
During the literature review several antioxidant system patterns were 
noticed. 
8-
isoprostane is produced when tocopherol amount in organism is falling; also 
inhibits thromboxane A2 pathway affecting the vascular endothelium growth factor. 
Protein carbonyls indicates the degree of oxidated proteins in, for instance, saliva or blood 
plasma. Both of them are lowered in tolerant organisms that indicates less oxidative 
damage. There is a cluster of antioxidant molecules that cooperate with each other. 
 
Transtiretin shows the oxidative statement in organism blood because of high 
sensitivity
to and following breakage from tetrameric to monomeric form. This fact shows 
the neutralization of reactive oxidative system by tetrametic transtiretin and thus 
decreasing this molecule indicates hypoxic conditions. 
Gluthation peroxidase
-
3 protects vascular endothelium from damage, coming from 
hydrogen peroxide and lipid hydroperoxides; serves as reactive oxidative system 
-
modified 
platelets and NO
-
derived oxidants against protector as well. Its quantity begins to rise to 
the response on hypoxia. Paraoxonase
-
1 prevents high and low density lipoproteins from 
oxidation. 
C
-
reactive protein influences the vascular endothelial growth factor and thus 
upregulates hypoxia inducible factor alpha
-
1 and matrix metalloproteinase
-
2 expression. 
Haptoglobin binds with hemoglobin which is released from injured red blood cells and 
prevents entrapment of nitric oxide by hemoglobin that may result in blood vessels 
contraction.
Hypoxia inducible factor alpha
-
1 activates angiogenesis patterns like vascular 
endothelial growth factor in first 2 hours in hypoxia condition and enhances the glycolysis. 
Matrix metalloproteinase
-
2 stimulates the extracellular matrix to degrade that obliquely 
improves oxygenation of tissues. 
Tocopherol reacts with alkoxy radicals, lipid peroxyl radicals and with alkyl radicals 
that disrupts endless loop of radical formation. Ascorbic acids obliquely influences the 
tocopherol regeneration and consequently the consistency of antioxidant system. There are 
also transporter GTP
-
related protein
Rab
-
3D and C
-
type lectin domain family 11 which are 
involved in equilibrating the statement of oxygen deficiency

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