Клиническая медицина Медицина и экология, 2021, 3



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Клиническая медицина 
The skin, as an organ, acts as the barrier 
between the external environment and the body 
[8, 10]. Various risk factors from the environment 
can produce, in certain circumstances, changes in 
skin structure and are associated with various 
skin diseases. In the context of environmental 
risk factors impacting upon the structure of the 
skin, these include pollutants, temperature 
changes, climatic variations, hormonal factors 
and, not least, exposure to ultraviolet radiation 
without adequate protection [11, 15]. 
Given these risk factors, there are numer-
ous external forces that can cause skin changes 
[7]. As well as associated pathologies, there are 
numerous studies that show how biomolecular 
mechanisms and pathophysiology are connected 
to changes to the skin, giving rise to dermatologi-
cal disorders [3, 14]. For these reasons, this 
study looks at, in addition to polluting factors, 
eating. This is a factor that can affect the func-
tionality of organs, although the effect is general-
ly viewed as tegumental [3, 5]. Similarly, changes 
that occur in the skin layers, producing altera-
tions in niveliul down to six layers, cause changes 
to subcomponents and ultrastructural type [1, 2]. 
The changes occur in the dermis and epidermis 
are linked to alternations to subcomponents. 
The study outlined in this paper is useful 
for examining skin pathology idea, particularly 
with the medical examination of children. Chil-
dren are the most commonly affected segment of 
the population. After this age group, as children 
become older, this condition is often followed by 
a degree of disability in relation to impaired tegu-
mentuilui. Older people have a high vulnerability 
to disease. Among the different dermatological 
disorders that affect the skin, melanocytic nevi 
are considered the most common pathology [14]. 
In context, melanocytic nevi can be found at an 
early age, those from childhood to old age [9, 
13]. 
The frequency spread of melanocytic nevi 
in the body segments is strictly interdependent 
with individual phenotype, with predisposing ge-
netic factors and exposure to harmful factors di-
rected towards the skin, such as exposure to ul-
traviolet radiation, are deemed to have a minor 
role [5]. From this perspective, what appear as 
benign melanocytic nevi may degenerate and 
become malignant [15]. Such changes to the skin 
can be demonstrated successfully on experi-
mental animal models [6]. 


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