Студенттер мен жас ғалымдардың «фараби әлемі» атты халықаралық ғылыми конференциясы
SYNTHESIS OF COORDINATION COMPLEX OF ZINC ACETATE (II) WITH
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Сборник конф Фараби Әлемі 2023 химфак-печать
| SYNTHESIS OF COORDINATION COMPLEX OF ZINC ACETATE (II) WITH
CYCLOHEXANONE OXYPHOSPHONATE Zharas A.S. 1,2 , Askar D. 1,2 , Zharkynbek T.Y. 2,3 Scientific supervisor: Dr.Sc., professor Yu V.K. 2 1 Kazakh-British Technical University, Almaty, Kazakhstan 2 A.B. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan 3 Al-Farabi Kazakh National University, Almaty, Kazakhstan jarassovaaruzhan@gmail.com Many of the most significant theoretical and practical achievements of organic chemistry in recent years are the result of the rapid development of one of its branches – the chemistry of organophosphorus compounds. Great achievements of organophosphate chemistry in the production of highly effective pesticides, medicines, plasticizers, chelators, and a number of other specialty materials, without which advances in agriculture, medicine and modern technology are impossible. The aim of this work is the synthesis of complex of cyclohexanone oxyphosphonate with zinc actetate (II), and further investigating it’s biological activity. It assumes that activity of oxyphosphonates can be increased by using them as complexes with microelements, and in addition can solve problem with metal ion deficit in organism. One of the most important macro and trace elements for the proper functioning of the human body is zinc. But today, more than 2 billion people are zinc deficient, leading to stunted growth, cognitive impairment and immune deficiency. The only stable form is the Zn 2+ ion, which enters the human body with water and food. Zn 2+ ions inhibit coronavirus RNA polymerase and inhibit virus replication in cell cultures. Synthesis of coordination compound was held under ultrasonic stimulation. Initial oxyphosphonate and acetate of zinc in 2:1 ratio were mixed in ultrasound bath at room temperature for 30 minutes. Then, about 5 ml ethanol was added as reaction medium and stirred until full dissolution. Closed reaction mixture was left for night to observe form of sedimentation and then transported to Petrie dish for evaporation. White crystalline precipitation was formed and collected with T m 96.4–99.6 о С. The results of the IR spectrum show the shift of the absorption band of the P=O bond in the long-wavelength region of 46 cm -1 with respect to the IR spectrum of the starting oxyphosphonate and indicates the formation of a complex. Before, study on the myelostimulating effect of its analogue of complex with manganese (II) acetate was investigated, in which the oxyphosphonate showed moderate activity and the complex high activity. Based on these results, it can be assumed that obtained oxyphosphonate in complex with zinc acetate may have similar biological activity. Synthesized complex was sent to al-Farabi biological faculty for investigation myelostimulating activity. The work was financially supported by the Committee for Quality Assurance in the Sphere of Education of the Ministry of Education of the Republic Kazakhstan, TFP BR18574042 «Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы 113 жүктеу/скачать 2,6 Mb. Достарыңызбен бөлісу:
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