Студенттер мен жас ғалымдардың «фараби әлемі» атты халықаралық ғылыми конференциясы


SYNTHESIS OF COORDINATION COMPLEX OF ZINC ACETATE (II) WITH



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SYNTHESIS OF COORDINATION COMPLEX OF ZINC ACETATE (II) WITH 
CYCLOHEXANONE OXYPHOSPHONATE 
 
Zharas A.S. 
1,2
, Askar D.
1,2
, Zharkynbek T.Y.
2,3 
Scientific supervisor: Dr.Sc., professor Yu V.K.
2
 
1
Kazakh-British Technical University, Almaty, Kazakhstan 
2
A.B. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan
3
Al-Farabi Kazakh National University, Almaty, Kazakhstan 
jarassovaaruzhan@gmail.com
 
Many of the most significant theoretical and practical achievements of organic chemistry in 
recent years are the result of the rapid development of one of its branches – the chemistry of 
organophosphorus compounds. Great achievements of organophosphate chemistry in the production 
of highly effective pesticides, medicines, plasticizers, chelators, and a number of other specialty 
materials, without which advances in agriculture, medicine and modern technology are impossible. 
The aim of this work is the synthesis of complex of cyclohexanone oxyphosphonate with zinc 
actetate (II), and further investigating it’s biological activity. 
It assumes that activity of oxyphosphonates can be increased by using them as complexes 
with microelements, and in addition can solve problem with metal ion deficit in organism.
One of the most important macro and trace elements for the proper functioning of the human 
body is zinc. But today, more than 2 billion people are zinc deficient, leading to stunted growth, 
cognitive impairment and immune deficiency. The only stable form is the Zn
2+
ion, which enters the 
human body with water and food. Zn
2+
ions inhibit coronavirus RNA polymerase and inhibit virus 
replication in cell cultures. 
Synthesis of coordination compound was held under ultrasonic stimulation. Initial 
oxyphosphonate and acetate of zinc in 2:1 ratio were mixed in ultrasound bath at room temperature 
for 30 minutes. Then, about 5 ml ethanol was added as reaction medium and stirred until full 
dissolution. Closed reaction mixture was left for night to observe form of sedimentation and then 
transported to Petrie dish for evaporation. White crystalline precipitation was formed and collected 
with T
m
96.4–99.6 
о
С. The results of the IR spectrum show the shift of the absorption band of the 
P=O bond in the long-wavelength region of 46 cm
-1
with respect to the IR spectrum of the starting 
oxyphosphonate and indicates the formation of a complex. 
Before, study on the myelostimulating effect of its analogue of complex with manganese (II) 
acetate was investigated, in which the oxyphosphonate showed moderate activity and the complex 
high activity. Based on these results, it can be assumed that obtained oxyphosphonate in complex 
with zinc acetate may have similar biological activity. Synthesized complex was sent to al-Farabi 
biological faculty for investigation myelostimulating activity. 
The work was financially supported by the Committee for Quality Assurance in the Sphere 
of Education of the Ministry of Education of the Republic Kazakhstan, TFP BR18574042 


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