2 тапсырма. ДНҚ - ның молекулярлық гибридизациясын менгеру
Бақылау сұрақтары:
1. Денатурация және ренатурация дегеніміз не?
2. Молекулярлы гибридизация не?
Әдебиеттер: 7.1.1-7.1.7 (негізгі), 7.2.8- 7.2.16 (қосымша)
Тақырып 11. Нуклеин қышқылдарының биосинтезі және деградациясы.
Сабақтың мақсаты: Матрицалық және матрицалық емес синтез. Марицалық синтез ингибиторлары.
1 тапсырма. ДНҚ, РНҚ, белок синтезіне қатнасатың заттарды менгеру.
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)
2 тапсырма.
Задание 2. Кестені дәптерге көшір
Антибиотиктар –матрицалық биосинтездін ингибиторлары
8 кесте
Антибиотиктар
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Механизм
действия
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Репликацияның ингибиторлары
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Дауномицин
Доксорубицин
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ДНҚ құрылымына кіреді репликациямен транскрипцияны бузады
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Актинрмицин D
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Мелфалан
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Репликацияны бузады
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Номермицин
Новобиоцин
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Репликациямен транскрипцияны бузады
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Транскрипцяның ингибиторлары
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Рифамициндер
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РНҚ полимеразамен қосылғанан кейын транскрипция пайда болуына кедергі жасайды
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Трансляцияның ингибиторлары
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Тетрациклины
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Элонгацияның ингибиторлары : 30S рибосома мен қосылады аа-тРНК А-центр қосылуны кедергі жасайды
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Левомицетин
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50S рибосомамен қосылады
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Эритромицин
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50S рибосома мен қосылады және транслокацияны ингибиторлайды
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Стрептомицин
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Трансляцияның инициайиясын ингибирлайды
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Бақылау сұрактар:
1. Матрицалық емес синтез дегеніміз не?
2. ДНҚ мен РНҚ матрицалық синтезі қалай жүреді?
Әдебиеттер: Бақылау сұрактар:
1.Рекомбинантты ДНҚ туралы түсініг.
2.Гендерді клондау қандай әдістерді білесіз?
Әдебиеттер: 7.1.1-7.1.7 (негізгі), 7.2.8- 7.2.16 (қосымша)
Тақырып 12.Тұқым қуалаушылықтың зат алмасуының және тасымалдануының молекулалық механизмі. Гендік инженерия.
Сабақтың мақсаты: ДНҚ репарациясы. Репарация түрлері. Гендік инженерия әдістерін менгеру.
1 тапсырма. Схема бойынша репарацияның кезендерің менгеру
Достарыңызбен бөлісу: |