«Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы
SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS
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| SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS
STRUCTURE Amanzholkyzy A. Scientific supervisor: Abilov Zh. A. Al-Farabi Kazakh National University arai13_95@list.ru In the case of the problem of antibiotic resistance in pathogenic microorganisms, the World Health Organization (WHO) urges the government of WHO member countries and scientists all over the world to intensify the search for new effective drugs that can withstand the spread of drug resistant microorganisms and the diseases caused by them. In a number of promising compounds for the control of drug-resistant pathogens, the semiorganic iodine coordination compounds with biologically active organic ligands and alkali metal halides are among the most perspective. Halogens have played an important role in the development of pharmaceuticals for several decades. The effectiveness of many complex molecules is significantly enhanced by the presence of halogen atoms. The majority of halogenated drugs contain fluorine, followed by chlorine, while those with bromine are rare. Only a few iodine-containing drugs are known, such as the thyroid hormone thyroxine, an anti-herpesvirus, the antiviral drug idoxuridine, and amiodaron, a class III antiarrhythmic agent. For a purposeful search for new iodine coordination compounds with biologically active ligands, it is necessary to study the influence of the ligand nature and structure of coordination compounds on pathogenic microorganisms at the molecular level, and to associate the structure with antimicrobial effectiveness. It is necessary to find out the mechanism of action of biologically active compounds on pathogenic microorganisms at the molecular level. This formulation of the problem emphasizes the importance of knowledge of atomic structures of compounds. Of all the modern physicochemical methods for studying the atomic structure of molecules, X-ray diffraction analysis (XRD) is the most reliable technique. The purpose of these studies was to determine and refine the crystal structure of the new coordination compound formed in the tryptophan:NaI:iodine system,and unit cell parameters were determined.A chemical structure of the compound wasdetermined by X-ray diffraction analysis asC 11 H 12 N 2 O 2 •(C 11 H 13 N 2 O 2 ) + •Na + •2Н 2 О • (I 4 ) 2- . The coordination compound showed low toxicity and exhibited bactericidal activity against both susceptible and multiresistant strains of bacteria S. aureus , P. aeruginosa , and E. coli . As a result semiorganic complex of iodine was synthesized and the crystal structure was observed C 11 H 12 N 2 O 2 •(C 11 H 13 N 2 O 2 ) + •Na + •2Н 2 О •(I 4 ) 2- . It has low cytotoxicity, direct antiviral effect, broad-spectrum antimicrobial activity against antibiotic-resistant strains of microorganisms and is therefore promising for further useas an active antimicrobial substance. «Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы 253 жүктеу/скачать 0,93 Mb. Достарыңызбен бөлісу:
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