Студенттер мен жас ғалымдардың «фараби әлемі» атты халықаралық ғылыми конференциясы

«Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы
324 
CREATION OF A BIOSENSOR ELECTRODE MODIFIED WITH MOLYBDENUM 
Imamussenova А.А. 
Scientific supervisor: Kudreeva L.K. 
Kazakh National University named after al-Farabi 
 
asal.imamusenova@mail.ru
 
 
Currently, the number of people suffering from cardiovascular disease is sharply growing 
year by year. Myocardial infarction is a disease characterized by the death of cardiac myocytes, 
which is due to an imbalance between the demand for blood by the cardiac tissue and the supply of 
blood.
The detection of cardiovascular disease biomarker can be defined by several methods. There 
are optical, electrochemical, and acoustic sensors. Among these electrochemical cardiac biosensors 
are reliable. 
Biosensors are analytical devices that use biological recognition elements, such as enzymes or 
antibodies, to detect and measure the concentration of specific analytes in a sample. 
Electrochemical biosensors are a popular type of biosensor that measure changes in the electrical 
properties of the sample in response to the analyte. One of the key components of an 
electrochemical biosensor is the electrode, which serves as the platform for the biological 
recognition element and the transducer for the electrochemical signal [1]. 
Molybdenum is a transition metal that has unique chemical and physical properties, making it 
a promising candidate for modifying electrode surfaces in biosensors. Molybdenum has a high 
electron transfer rate, good biocompatibility, and can form strong chemical bonds with 
biomolecules, making it an attractive choice for improving the sensitivity and selectivity of 
biosensor electrodes [2]. 
The biosensor electrode was prepared by depositing molybdenum on the electrode surface 
using electrodeposition technique. The performance of the modified electrode was compared with 
that of the unmodified electrode using cyclic voltammetry, impedance spectroscopy, and 
electrochemical impedance spectroscopy. The sensitivity and selectivity of the modified electrode 
were evaluated for the detection of cardiovascular biomarker such as troponin I (cTnI). 
The results showed that the modified electrode had a higher sensitivity and selectivity for the 
detection of cardiac biomarker, such as cTnI, cTnII, compared to the unmodified electrode. The 
modified electrode exhibited a larger current response and lower detection limit for these analytes. 
The electrochemical properties of the modified electrode were also improved, with lower charge 
transfer resistance and higher electron transfer rate. 
The suggested biosensor can identify biomarkers at concentrations between 0.04 and 5 
ng/mL. In our project, the electrochemical biosensor that our team is now developing will be used 
to measure the level of cTnI in pure serum and pure blood plasma, which have not previously been 
thoroughly explored. 

«Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы
325 

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