1.
List of exam topics
Discipline "Methodology of systemic genetic research"
The subject and objectives of modern genetics
Methodology of modern genetics. Using the laws of classical genetics in systems analysis. Empirical
levels and procedures of scientific inquiry.
Subjects,
objectives,
prospects,
and methods of different
genetics (pharmacogenetics, environmental genetics, radiation genetics, medical genetics, oncogenetics,
immunogenetics, etc.). Heredity, inheritance, heritability.
Model objects and their role in genetic research.
Biological features of model objects and their role in genetic research.
The main differences in the
organization of cells of prokaryotes and eukaryotes. Application of knowledge about the life cycles of
plants and animals in genetic experiments. The selection of a model object following the purpose and
objectives of the study. Bioethics issues and risks.The problem of extrapolating to
humans the results of
testing mutagens obtained using various model objects.
Cytogenetic research methods.
Basic principles of cytogenetic analysis. Modern cytogenetic methods for testing the mutagenic activity
of environmental factors and assessing its quality. Differential chromosome staining methods.
Karyotyping.
Genetic maps of chromosomes and their practical application. Diagnostic problems of fetal karyotyping.
Sex chromatin.
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